225 Ruf Road, Orangeburg SC 29118
From Exit 145
Proceed onto Route 601 and travel 1.4 miles to the 3rd stoplight. Turn right onto St. Matthews Road and you’ll find Ruf Road .4 miles ahead on your left. Look for the street sign that says “SPCA” to guide you to our location.
Travel along St. Matthews Road, heading away from town, past the Hillcrest Recreation Center and the YMCA. Ruf Road will be the next road you come across on your right.